CK20 versus AMACR and p53 immunostains in evaluation of Urothelial Carcinoma in Situ and Reactive Atypia

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Differential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: Analysis of CK20, CD44, P53 and Ki67

Background: Flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Urothelial dysplasia and CIS are associated with the recurrence and progression of urothelial carcinoma. Distinguishing CIS and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. Using different immunohistochemical mark...

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differential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: analysis of ck20, cd44, p53 and ki67

background: flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (cis). urothelial dysplasia and cis are associated with the recurrence and progression of urothelial carcinoma. distinguishing cis and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. using different immunohistochemical mark...

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differential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: analysis of ck20, cd44, p53 and ki67

background: flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (cis). urothelial dysplasia and cis are associated with the recurrence and progression of urothelial carcinoma. distinguishing cis and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. using different immunohistochemical mark...

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Differential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: Analysis of CK20, CD44, P53 and Ki67

BACKGROUND Flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Urothelial dysplasia and CIS are associated with the recurrence and progression of urothelial carcinoma. Distinguishing CIS and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. Using different immunohistochemical marke...

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ژورنال

عنوان ژورنال: Diagnostic Pathology

سال: 2020

ISSN: 1746-1596

DOI: 10.1186/s13000-020-00984-2